As depicted in Supplemental Figure S2a, there were seven upregulated genes (ARA55, GNAO1, GNB3, POLR2L, PRKCE, PRKD1, and TBP) and one down-regulated gene (CALR), leading to a statistically significant (P < 0.05) overrepresentation in the AR signaling pathway of AA PCa patients (see figure legend in Supplemental Figure S2 for full gene names). This evidence concerns the gene GNAO1 and posterior cortical atrophy.