Interestingly, individual knockdown of RHOA, ITGB5, and PIK3CB slightly reduced the basal (i.e., vehicle treatment/no DHT) invasion potential of the AA cell lines by 20–40% (Figure 5(b), open bars), suggesting that the weak AR binding observed in some target genes under androgen-limited conditions may still contribute to PCa progression/invasion (see vehicle treatment ITGB5 and PI3KCB in Figure 4(b) and [61]). Here, AR is linked to posterior cortical atrophy.