As depicted in Supplemental Figure S2a, there were seven upregulated genes (ARA55, GNAO1, GNB3, POLR2L, PRKCE, PRKD1, and TBP) and one down-regulated gene (CALR), leading to a statistically significant (P < 0.05) overrepresentation in the AR signaling pathway of AA PCa patients (see figure legend in Supplemental Figure S2 for full gene names). Here, POLR2L is linked to posterior cortical atrophy.