SLC38A7 and ischemia: In addition to the cell plasma membrane damage discussed previously, and in the case of neurotransmitter amino acids Ca2+-dependent exocytosis from synaptic vesicles [26], the mechanisms involved in the release of amino acids in ischemia may include swelling-evoked release via anion channels [27], reversal of amino acid transporters in depolarized cells [28], or acidosis-induced failure of reuptake into neurons and glia [29].