The effects of VIP and PACAP are mainly mediated through VPAC1 and VPAC2 receptors [1], [4], and they are involved in many physiological and pathophysiological processes, such as growth, cancer, immune responses, circadian rhythms, the control of neuronal and endocrine cells, and functions of the digestive, respiratory, reproductive and cardiovascular systems [10]. This evidence concerns the gene VIPR1 and cancer.