Therefore, the relationship between UCP loci and susceptibility to T2DM has been investigated in a number of genetic studies and particular attention has been focused on the -3826A/G (rs1800592) polymorphism in the promoter region of the UCP1 gene, the -866G/A polymorphism (rs659366) in the promoter region, the Ala55Val (C/T; rs660339) polymorphism in exon 4 and the Ins/Del polymorphism, which is an insertion/deletion of 45 bp in the 3′ untranslated region (3′UTR) of exon 8 of the UCP2 gene, and the -55C/T (rs1800849) polymorphism in the promoter region of the UCP3 gene. Here, UCP2 is linked to type 2 diabetes mellitus.