In the present study, the only one to our knowledge exploring the prognostic role of IGF1R in early laryngeal cancer, we have shown that increased IGF1R-alpha cytoplasmic and/or membraneous expression, as assessed by immunohistochemistry and quantified with the IRS system, is an independent adverse prognostic factor for recurrence and survival in patients with early (surgically resected) squamous-cell carcinoma of the larynx. The gene discussed is IGF1R; the disease is laryngeal squamous cell carcinoma.