Interestingly, the well-known tumour suppressor and DSB repair protein BRCA1, whose optimal relocalisation to subnuclear foci at DNA lesions requires MDC1 (in the presence of DSBs) and a proficient FANC pathway (in response to ICLs), was recently shown to be involved in the response of cells to UVC [19], [34]. The gene discussed is BRCA1; the disease is neoplasm.