MYC and neoplasm: Rinaldi et al. (2007) showed that both MYC and the miRNA cluster miR-17-92 are amplified in human mantle cell lymphoma [17]; Frenzel et al. (2010) described miR-9 as an oncogenic miRNA and let-7 as a tumor suppressor miRNA both of which are regulated by MYC [12]: MYC induces miR-9, which blocks tumor suppressor pathways, while MYC inhibits let-7, which blocks oncogenic pathways.