LYN and chronic myelogenous leukemia, BCR-ABL1 positive: This upregulation of CXCR4 by imatinib was mechanistically dissected by showing a redistribution of CXCR4 in the lipid raft fraction of CML cells, where it colocalized with phosphorylated Lyn, suggesting that therapeutic targeting of the CML cell lipid raft is a viable option in preventing chemoresistance [78].