Several studies in Vero and Jurkat cell lines as well as mouse embryonic fibroblasts (MEFs) from cathepsins B and L deficient mice have demonstrated that proteolytic cleavage of EBOV GP by these lysosomal cysteine proteases removes the glycan cap and MLR of GP1 to produce a stable GP intermediate, which is necessary for infection [66, 73–75]. The gene discussed is CTSB; the disease is infection.