MMP8 and coronary artery disorder: By sequencing the MMP-8 gene proximal promoter and coding regions and tagging single nucleotide polymorphisms (SNP) in the introns, 5′ upstream sequence and 3′-untranslated region in CAD patients (n = 1000), Laxton and colleagues have detected an association between the extent of coronary atherosclerosis and SNP rs19440475 [28].