Interestingly, leucine supplementation (1.5% in drinking water for eight months) carried out in the polygenic mouse model NONcNZO10/LtJ (RCS10), which is predisposed to beta cell failure and type 2 diabetes, is able to improve the glycemic control that was associated with an increased insulin response to food challenge in control mice [23]. Here, INS is linked to type 2 diabetes mellitus.