However, conclusions should not be drawn by direct comparisons of the results with the other studies using Nrf2-KO mice as this study used female mice while the others used male; as has been previously described, the presence of high estrogens concentration in the female mice may attenuate at a degree the effects of HFD-induced obesity [52]. Here, NFE2L2 is linked to obesity due to melanocortin 4 receptor deficiency.