NFE2L2 and obesity due to melanocortin 4 receptor deficiency: This study did not reveal if Nrf2 signaling is implicated in obesity as it was short-term and the mice had not become markedly obese, but it described that in the initial days of HFD feeding Nrf2 is down-regulated and that complete absence of Nrf2 increased the expression of lipid and cholesterol synthesis genes.