At a closer look, while the two LMNA mutations described in our study share very similar cardiac phenotypes (conduction abnormality, hear failure, ventricular tachyarrhythmia) with the previous reported LMNA mutation causing autosomal Emery-Dreifuss muscular dystrophy [41] presumably due to halo-insufficiency studied in the mouse models [17. This evidence concerns the gene LMNA and Emery-Dreifuss muscular dystrophy.