INS and diabetes mellitus: Many miRNAs are involved in DM physiopathology: for instance, miR-375 controls β cell mass and insulin secretion [17]; miR-21 and miR-146a are involved in β-cell apoptosis [18]; miR-30d promotes insulin synthesis and protects β cells from damage by proinflammatory cytokines [19]; miR-126 is responsible for impaired angiogenetic signaling in DM patients [20].