However, isolated PBMCs from PTSD patients spontaneously produced significantly higher amounts of IL-1β (F = 11.31, p = .0003), IL-6 (F = 7.27, p = .005) and TNF-α (F = 5.01, p = .02) than PBMCs from controls (Figure 1A-C). This evidence concerns the gene IL1B and post-traumatic stress disorder.