The primary research objective of this study was to describe how host iron status at HIV diagnosis indicated by plasma iron status biomarkers and iron-genes, including solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (SLC11A1) operating at the level of the macrophage, were associated with the later development of TB in HIV infection. This evidence concerns the gene SLC11A1 and HIV infectious disease.