TP53 and hepatocellular carcinoma: [55]. MiRNA-199a/b-3p is reported to be down-regulated in HCC and it increases sensitivity to DOX-induced apoptosis by targeting mTOR and c-met. We got the same results with lower expression level of miRNA-199a-3p in HepG2/DOX cells [24], [56]. Besides, we also found that miRNA-296 have a very high expression level in HepG2/DOX cells. This miRNA can suppress p53 function in cancer cells and might contribute to overcome DOX challenge [57].