TP53 and cancer: Among the 47 genes located in the 17p13 locus, besides TP53 gene, 3 genes could be involved in the high cell proliferation rate induced by LOH: Claudin-7, SERPINF1, and SMYD4. The reduced expression of Claudin-7 gene was correlated with a strong invasion, migration and metastasis ability of cancer cells [15]–[16].