In the example of CaMV, it is known that microtubules are involved in the generation of TBs at the onset of infection (Martinière et al., 2009) and that the microtubule depolymerizing drug oryzalin inhibits virus acquisition by aphids (Martinière et al., 2011a), but any details of the mode of action of oryzalin on TBs and how TBs function in virus transmission are still unclear. The gene discussed is SALL1; the disease is infection.