HPGDS and asthma: Recent studies of genes-environment interaction or effect modification for asthma mainly focused on members of the glutathione-S-transferase (GST) superfamily because several members, particular in glutathione-S-transferase p1 (GSTP1), glutathione-S-transferase m1 (GSTM1) and glutathione-S-transferase t1 (GSTT1), are expressed in the respiratory tract and function in processes implicated in asthma pathogenesis, including oxidant defenses, xenobiotic metabolism, and detoxification of hydroperoxides.