Due to common nature of diabetes we have included samples with this disease into our control dataset, but have excluded ovarian cancer samples because cancer as well as cancer therapies are known to alter epigenetic marks [51] and somatic KDM5C mutation was previously identified in cancer [52,53]; trisomy 21 cases were also excluded due to overlapping ID phenotype with KDM5C mutations cases [50]. The gene discussed is KDM5C; the disease is ovarian cancer.