The genes FBXL5, SCMH1 and CACYBP on which we focused in our downstream analysis have exhibited a surprisingly large degree of DNA methylation differences between cases and controls reminiscent of the DNA methylation alterations at imprinted loci in disorders affecting neurodevelopment, such as Prader-Willi and Angelman syndromes [71,72]. The gene discussed is SCMH1; the disease is Angelman syndrome.