There was a small (median differences = 0.01-0.04) but highly significant increase of DNA methylation in females compared to males in FBXL5 and CACYBP (p < 1.00E-04) and a trend towards significance for SCMH1 (p = 0.07), in the diabetes study where samples of both sexes were included [27] (Figure 6). Here, CACYBP is linked to diabetes mellitus.