INS and obesity due to melanocortin 4 receptor deficiency: However, the body mass index (BMI), a calculation (kg/m2) based on weight and height that is used to define “overweight” and “obesity,” does not account for all variances in insulin sensitivity and cardiometabolic risk.44 Furthermore, there is considerable debate as to the metabolic differences between visceral and subcutaneous fat and the role of these fat depots in cardiometabolic disease.