ZFHX3 and fragile X syndrome: Finally, to gain insight into the potential mechanism(s) behind FXS-associated DNA methylation changes, we annotated the genome for all CGG trinucleotide repeats containing at least eight consecutive repeats (N = 136 tracts; N = 452 probes; see Methods) and found two juxtaposed probes annotated to ZFHX3 that reached significance (Additional file 6: Table S3).