Given the role of Hedgehog signaling in inducing EMT through multiple regulators, such as Snail, ZEB1, ZEB2, Twist1, Twist2, and FOXC2, [17] we analyzed the relationship between Gli2 expression and that of E-cadherin, N-cadherin and vimentin in the 68 HCC samples. This evidence concerns the gene ZEB2 and hepatocellular carcinoma.