Further analysis by real time RT-PCR showed that transcripts encoded by multiple genes implicated in host responses to viral infections of the brain were increased in the HIV/AIDS brains (HIV4, 7–10, n = 5)) with cd3ε, egf and il-23 showing significant increases compared to ODC brains (ODC6-10, n = 5)) (Figure 2C). This evidence concerns the gene EGF and viral infectious disease.