CD47 and type 1 diabetes mellitus: Although this model is imperfect in that it is a CD47-deficient model, where CD47 is implicated in apoptosis, phagocytosis, cell migration, and T cell responses (Oldenborg, 2004; Chao et al., 2012), it is nevertheless a spontaneous model of T1D wherein the results complement the findings of Ford et al. (2007) suggesting that DN T cells may be of therapeutic interest for T1D.