Although the flagellated trypomastigotes released from pseudocysts may rapidly move away from the primary foci of infection, hence seeking for safer targets elsewhere in the myocardium, we proposed that the transient rise of plasma proteins in the edematous interstitial spaces might favor generation of infection-promoting peptides, such as bradykinin (BK), in the peripheral tissues (Scharfstein et al., 2000; Todorov et al., 2003; Andrade et al., 2012). This evidence concerns the gene KNG1 and infection.