In addition, mice deficient in RORα or RORγ displayed a diminished susceptibility to allergen-induced lung inflammation and collagen-induced arthritis (Jaradat et al., 2006; Tilley et al., 2007) and polymorphisms in RORα have been associated with increased susceptibility to asthma (Ramasamy et al., 2012). This evidence concerns the gene RORC and asthma.