The 491 target gene set is also significantly overexpressed in MLLr ALL compared to several other B-ALL subtypes (E2A-PBX1, ETV6-RUNX1, and pre-B; Figure S1E–S1G), although not others (e.g., BCR-ABL; Figure S1G). The gene discussed is PBX1; the disease is acute lymphoblastic leukemia.