RUNX1 siRNA knockdowns inhibited clonogenicity of t(4;11) (SEM and MV4-11) cells but not MLL-AF9 (THP-1) cells, indicating that the oncogenic role for RUNX1 in t(4;11) leukemia appears to be t(4;11) specific but lineage independent, with both B-ALL (SEM) and AML (MV4-11) affected. This evidence concerns the gene KMT2A and acute myeloid leukemia.