Average HOXA9, HOXA10, and CDKN1B expression is significantly higher in MLLr leukemias than in other ALL subtypes (Figures 2C–2E and S2B–S2G; Table S2), but no significant difference in expression levels is seen when comparing MLLr and t(4;11) leukemias (in the Eastern Cooperative Oncology Group [ECOG] E2993 patient set, the only set where this MLLr cytogenetic information is available; Figures 2E, S2D, and S2G; Table S2). The gene discussed is CDKN1B; the disease is leukemia.