Since the first two heterozygous MPL point mutations were identified in congenital amegakaryocytic thrombocytopenia (CAMT) in 1999, mutations in hereditary thrombocythaemia (HT), myeloproliferative neoplasms (MPNs), refractory anaemia with ringed sideroblasts associated with marked thrombocytosis (RARS-t) and acute myeloid leukaemia (AML) have been identified [22]. Here, MPL is linked to acute myeloid leukemia.