Corticosteroids [11,12], anti Tumor Necrosis Factor α (TNF α) antibodies [13,14], Anti Interleukin 1 antibodies [15], Platelet Aggregating Factor (PAF) antagonist [16,17], antioxidants especially selenium [18,19], modulation of nutrition [20], modulation of coagulation [21] and complement pathway [22] are examples of immunotherapy in sepsis, but none of them were effective on survival of patients. Here, TNF is linked to Sepsis.