As observed in Table 3, both the expression of GFRα1 and GFRα3 protein were significantly associated with tumor LNM (P = 0.001 and P = 0.006), higher clinical stage (P = 0.001 and P = 0.008) and HER-2 positive expression (P = 0.030 and P = 0.005) respectively. This evidence concerns the gene ERBB2 and neoplasm.