In the UK the National Institute for Health and Clinical Excellence (NICE) recommends evaluation of possible causes of anaemia where Hb ≤ 11 g/dl and treatment with intravenous iron and erthyropoiesis-stimulating agents (ESA) to maintain Hb in the range 10-12 g/dl [24,25]. The gene discussed is GSTM1; the disease is anemia.