PRIMA-1 increased phospho-p53 (Ser15) content in Akt down-regulated cells treated with CDDP, suggesting that the action of PRIMA-1 in facilitating CDDP-induced apoptosis in p53 mutant chemoresistant ovarian cancer cells may in part be mediated through increased p53 phosphorylation at Ser15 (Figure 4). This evidence concerns the gene PRIMA1 and ovarian cancer.