PRIMA-1 increased phospho-p53 (Ser15) content in Akt down-regulated cells treated with CDDP, suggesting that the action of PRIMA-1 in facilitating CDDP-induced apoptosis in p53 mutant chemoresistant ovarian cancer cells may in part be mediated through increased p53 phosphorylation at Ser15 (Figure 4). The gene discussed is TP53; the disease is ovarian cancer.