TP53 and Familial prostate cancer: Resveratrol (RSV), a natural polyphenol compound, was shown to enhance prostate cancer cell response to irradiation by 1) inhibiting activation of Akt, 2) enhancing activation of ATM and AMPK pathways, and 3) effecting pathways encompassing p53, p21, and p27, which are associated with early cell cycle arrest.