Particularly, the complement-like thioester-containing protein 1 (TEP1), an anti-parasitic factor controlling infection in rodent and human malaria, exhibits extremely large nucleotide diversity and analysis of the sequence polymorphisms has lead to the distinction of different alleles, 2 resistant (R1, R2) and 2 susceptible (S1, S2) [66], [68]. The gene discussed is TEP1; the disease is infection.