A loss of heparan sulfate proteoglycans in the GBM contributes to proteinuria in glomerular diseases including DN [11], [31] and quantitative and qualitative changes in the de novo synthesis of heparan sulfate proteoglycan core protein and/or sulfation pattern of the heparan sulfate glycosaminoglycan chains have been proposed as pathogenic mechanisms [27], [32]. The gene discussed is CD44; the disease is liver dysplastic nodule.