IRF5 and systemic lupus erythematosus: To this end, we provide intriguing data to be built upon in the near future that suggests genotype may define, not only the top four most abundant transcripts expressed in Mo of SLE patients with the H2 risk haplotype, but the IRF5 transcript signature itself, as patients carrying the H2 risk haplotype clustered tightly together (Fig. 6B).