Indeed, it has been hypothesized that an IRF5-SLE risk haplotype will confer changes in IRF5 transcription, protein/isoform expression, and biological function [4], [7]–[8], [10], [36]; however, recent data from traditional cloning and sequencing suggests that haplotype does not alter the profile of transcripts expressed [8]. The gene discussed is IRF5; the disease is systemic lupus erythematosus.