Particularly, our observation supports a recent report from Li et al. [41], in which HPV 16 E6 overexpression in lung cancer cells significantly promotes angiogenesis via enhancing the expression of several pro-angiogenic factors such as HIF-1a, VEGF and IL-8.Earlier studies suggest that IL-8-mediated inhibition of apoptosis could be dependent or independent of Bcl-2 expression [25], [42]. The gene discussed is HIF1A; the disease is lung cancer.