P2RY2 and infection: One GPCR family of particular interest in the context of epithelial injury and wound responses includes purinergic receptors, which are activated by epithelial release of ATP in response to both mechanical and molecular stresses [8], [9], and are critical in epithelial responses to injury or infection promoting mucociliary clearance and stimulating cellular repair mechanisms [8], [10], [11], [12], and transactivation of EGFR has been implicated in these ATP-mediated wound responses in various cell systems [13], [14], [15].