In rats with DHT-induced PCOS, which have insulin resistance, obesity, and a PCOS phenotype including estrous cycle irregularities and ovaries with multiple large atretic antral follicles, low-frequency EA 3 times weekly for 4–5 wks increases insulin sensitivity (euglycemic hyperinsulinemic clamp) and modulates expression of genes related to insulin resistance, obesity and sympathetic activity in adipose tissue [20], [21], [22]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.