Thus, in skeletal muscle either JNK-1 and JNK-2 contribute cooperatively to the development of obesity-associated insulin resistance or alternative kinases such as atypical PKC- and DGK-activation may play a more important role in the development of obesity-induced insulin resistance in this organ [27], [30]. This evidence concerns the gene PRRT2 and obesity due to melanocortin 4 receptor deficiency.