While our report clearly demonstrates that skeletal muscle-specific JNK-1 deficiency is not sufficient to protect against obesity-associated insulin resistance, a recent report indicates that inactivation of JNK-1 in the adipose tissue causes some degree of protection from obesity-associated insulin resistance due to the inactivation of JNK-1 in adipose tissue [7]. The gene discussed is MAPK8; the disease is obesity due to melanocortin 4 receptor deficiency.