CPA1 and infection: Following the whole differentiation protocol and infection with LvGFP (Fig. 1), RBPL-ES cultures showed a limited but significant increase in a subset of secretory enzymes (Cpa1, Amyl, ChymoB1) in comparison with LvGFP-infected GFP-ES cultures (Fig. 7A), while the levels of endodermal and pancreatic progenitor markers at previous stages remained similar in both conditions (not shown).