In addition, comparisons of northern populations (Han Chinese, Japanese&Korean) and the other southern populations (SouthernChinese&Thai1, SouthernChinese&Thai2, Southeast Asian) revealed that immunoglobulin (Ig) subtype 2 domain and plenty of immune-associated pathways were significantly differentiated between north and south, such as pathways of graft-versus-host disease, autoimmune thyroid disease, asthma and viral myocarditis, and pathways of allograft rejection, antigen processing and presentation, and intestinal immune network for IgA production (Benjamini FDR corrected p<0.05). Here, CD79A is linked to autoimmune thyroid disease.