Using the Aldefluor assay to assess the presence and size of the cell population with ALDH enzymatic activity in our panel of four NSCLC cell lines, a significant increase in ALDH activity was demonstrated within each population of CisR cells relative to parent cells (Fig. 8A) as illustrated by representative dot plots and mean fluorescence intensity histograms (Fig. 8B). The gene discussed is LDHA; the disease is non-small cell lung carcinoma.