In LNCaP PCa cells in the absence of androgens, H2-relaxin mediated phosphorylation of Akt and GSK-3β caused the stabilised cytoplasmic accumulation of β-Catenin which subsequently bound to the AR and translocated into the nucleus, suggesting that the presence of androgens is not essential for the interaction between AR and β-Catenin under certain conditions [11]. This evidence concerns the gene AR and posterior cortical atrophy.