IKBKB and chronic obstructive pulmonary disease: Secondly, to profile 2 strains of genetically modified mice missing functional IKK-2, a key NF-κB signalling kinase in purported COPD effector cells (specifically, in airway epithelial cells (IKK-2ΔEpi) or in cells of myeloid lineage (IKK-2ΔMye)) in the model systems.