To test if IKK-2 in cell types other than epithelial cells or myeloid cells (or a combination of all cell types) could be involved in the CS-induced models, we used pharmacological inhibitors of IKK-2 (TPCA-1 and GSK 657311A) and compared them with a clinically relevant glucocortoid, budesonide. The gene discussed is IKBKB; the disease is Cowden syndrome 1.