CHUK and Granuloma: Some granulomas in IKKα cKO mice developed into very large, macroscopically discernable structures that contained a central core filled with necrotic and cellular debris (Fig. 4E; note that panel 4E is a lower magnification than 4D and 4F), and although large, these structures were well contained by a cuff of mononuclear cells, epitheloid histiocytes and occasional lymphocytes.