HK2 and diabetes mellitus: Since reduced glucose-6-phosphate content in muscle has been demonstrated in pre-non-insulin-dependent diabetes mellitus (pre-NIDDM) and NIDDM subjects, HK2 was investigated as a promising candidate gene for noninsulin-dependent diabetes mellitus (NIDDM; OMIM125853) [17], [18]; however, those studies concluded that mutations of the HK2 gene, including a common p.Gln142His polymorphism is not a major etiologic factor for NIDDM in the Finnish [17], [18], [19], [20], British [19], and Danish [20] populations.