HK2 and open-angle glaucoma: The rs678350 in the HK2 gene coding sequence showed significant allelic (p = 0.043 in Stage One, p = 0.0027 in Stage Two, 2.7XE-4 in meta-analysis association with POAG, and significant allelic (p = 0.004 in Stage One, p = 4.7XE-4 in Stage Two, 1.0XE-5 in meta-analysis) association with NTG (Table 2).