The SNP rs2033008 in the NCK2 gene showed a significant difference in allelic frequency (p = 0.015 in Stage One, p = 0.0053 in Stage Two, and 2.2XE-4 in meta-analysis) between controls and NTG, but not between control and POAG status (p = 0.147 in Stage One, 0.35 in Stage Two, 0.12 in meta-analysis) (Table 2 and Table 5). This evidence concerns the gene NCK2 and open-angle glaucoma.