DNMT1 has been previously shown to interact with PRC component EZH2 and to methylate PRC targeted genomic regions [32], therefore increased DNMT1 levels in malignant meningiomas may be recruited to PRC-targeted CpG islands and induce focal DNA hypermethylation. The gene discussed is EZH2; the disease is Anaplastic (Malignant) Meningioma.