For the malignant meningiomas in our study, 26 genes were identified as significantly hypermethylated at promoter CpG islands, including eight genes involved in the biological pathway of neurogenesis (BARHL2, TLX3, FOXR1, HOXA11, HOXA6, HOXA9, OTX2 and PAX3). This evidence concerns the gene OTX2 and meningioma.